Distinguishing the Olfactory Epithelium using an FDA-Approved Dye and Machine Learning Classification
Event Description
Abstract: Olfaction plays an essential role in everyday life. Anosmia, the loss of the sense of smell, affects approximately 20% of adults globally and its prevalence rises with age. This can lead to malnutrition, reduced ability to detect environmental hazards, and high rates of depression. The olfactory epithelium (OE) is a specialized tissue deep within the nasal cavity that primarily contains olfactory sensory neurons (OSNs), which are crucial cells that detect odorants and relay information to the olfactory neural pathway. Current clinical assessments for anosmia cannot discern whether the cause lies within the OSNs (sensorineural) or further down the pathway (central). The ability to image the OE would help assess the health of OSNs, distinguish between sensorineural and central causes of anosmia, and inform treatments. However, the OE is a small region of tissue that is non-uniform and difficult to distinguish from its surrounding respiratory epithelia (RE). This work explores the use of an FDA-approved dye, Indocyanine Green (ICG), to highlight tissue structure differences and help distinguish between OE and RE. We found that machine learning models using texture analysis information were able to classify images of the two tissue types correctly with ~80% accuracy, while a convolutional neural network was able to classify the images directly with ~90% accuracy. This advancement will enable accurate identification and mapping of the spatial distribution of OSNs within the nasal cavity, enhancing studies on olfactory degeneration and regeneration.
Bio: Skylar Suarez has a Bachelor of Science degree in Computer Science and Engineering from the University of South Florida. She spent nearly a decade as a software and hardware engineer, then decided to follow my dream of being involved in medicine and becoming a professor. She is a PhD Candidate at the Department of Biomedical Engineering at the University of Colorado Anschutz Medical Campus, where she also teaches courses in biological data analysis and machine learning. She specializes in neural engineering, particularly in the development and design of neurosurgical tools for assessing neurodegenerative disorders.
Location: New Computer Science, Room 220 OR Join by Zoom
Bio: Skylar Suarez has a Bachelor of Science degree in Computer Science and Engineering from the University of South Florida. She spent nearly a decade as a software and hardware engineer, then decided to follow my dream of being involved in medicine and becoming a professor. She is a PhD Candidate at the Department of Biomedical Engineering at the University of Colorado Anschutz Medical Campus, where she also teaches courses in biological data analysis and machine learning. She specializes in neural engineering, particularly in the development and design of neurosurgical tools for assessing neurodegenerative disorders.
Location: New Computer Science, Room 220 OR Join by Zoom
